منابع مشابه
TOXICOLOGICAL STUDIES ON CERTAIN AMINOALKYL ETHERS AS POTENTIAL LONG-ACTING LOCAL ANAESTHETICS
The acute intravenous toxicities of a selection of three potential long-acting local anaesthetics belonging to the series of2- phenoxyethyldialkylamine were determined in mice. Two of the compounds were tertiary amines and the third a quaternary ammonium derivative.The I.V. median lethal dose, (LDso) of one of the tertiary compounds, 21A [N, N- diethyl-2- (2,6- diisopropyl) ethyl amine hyd...
متن کاملPHARMACOLOGICAL STUDIES ON NOVEL BASIC AMINOALKYL ARYL ETHERS AS POTENTIAL LOCAL ANAESTHETICS
Following our previous investigations on certain new aminoalkyl aryl ethers, which showed promising and outstanding local anaesthetic properties, the local anaesthetic activity and duration of action of a further selection of four novel derivatives of the above-mentioned series, used as hydrochloride salts, have been determined by the ill vivo rat sciatic nerve test. These are: N,N-dimethyl...
متن کاملA comparison of local anaesthetics for venepuncture.
AIM To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS Single blind study in 120 children. RESULTS Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).
متن کاملQuinidine like activity of eight local anaesthetics.
and Md., Eight synthetic local anaesthetics from among (he Propiophenones, Benzil and Phenoxy derivatives and derivatives of Benzyl alcohol wen' examined for their arrhvthmia combating activity. Against acetylcholine induced auricular fibrillation U·0045 showed maximum activity and U -0172, U·OI77, U-OS75 and Lignocaine were more active than quinidine. In aconitine induced fibrillation li.OI77,...
متن کاملIgE-mediated reaction to local anaesthetics.
Local anaesthetics (LAs) are essential agents in daily practices of dentistry, minor surgery and dermatology. Although they have an impressive history of safety and efficacy, LAs also have the potential to produce adverse events, which are mainly of non-immune nature. The true IgE-mediated allergies are quite rare, but are more considerable in terms of ability to cause life-threatening outcomes...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1948
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1948.tb00389.x